Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke

Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke

Acute ischemic stroke treatment faces an unresolved obstacle as capillary reperfusion remains insufficient after thrombolysis and thrombectomy causing neuronal damage and poor prognosis. Hypoxia-induced capillary constriction is mediated by actomyosin contraction in precapillary smooth muscle cells...

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Main Authors: Pénzes, Máté, Túrós, Demeter, Máthé, Domokos, Szigeti, Krisztián, Hegedűs, Nikolett, Rauscher, Anna Ágnes, Tóth, Péter, Ivic, Ivan, Padmanabhan, Parasuraman, Pál, Gabriella, Dobolyi, Árpád, Gyimesi, Máté, Málnási-Csizmadia, András
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2021
Subjects:
Science::Medicine
MCAO
Reperfusion
Online Access:https://hdl.handle.net/10356/147000
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/147000

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