Ethnicity-specific skeletal muscle transcriptional signatures and their relevance to insulin resistance in Singapore

• Main Authors: Tan, Amelia Li Min, Langley, Sarah R., Tan, Chee Fan, Chai, Jin Fang, Khoo, Chin Meng, Leow, Melvin Khee-Shing, Khoo, Eric Yin Hao, Moreno-Moral, Aida, Pravenec, Michal, Rotival, Maxime, Sadananthan, Suresh Anand, Velan, S. Sendhil, Venkataraman, Kavita, Chong, Yap Seng, Lee, Yung Seng, Sim, Xueling, Stunkel, Walter, Liu, Mei Hui, Tai, E. Shyong, Petretto, Enrico
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; False Discovery Rate; Protein-Kinase-C
• Online Access: https://hdl.handle.net/10356/147055
• Institution: Nanyang Technological University

Context - Insulin resistance (IR) and obesity differ among ethnic groups in Singapore, with the Malays more obese yet less IR than Asian-Indians. However, the molecular basis underlying these differences is not clear. Objective - As the skeletal muscle (SM) is metabolically relevant to IR, we...