Cellular electron tomographic analysis of heterochromatin

• Main Author: Chan, Harvey Yin Seng
• Other Authors: Curtis Alexander Davey
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2021
• Subjects: Science::Biological sciences::Human anatomy and physiology::Deoxyribonucleic acids; Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/147313
• Institution: Nanyang Technological University

Packaging of nucleosomes into heterochromatin is an intricate process as many factors are involved in silencing of the transcriptional machinery in specific regions of DNA. Chromatin structure in vivo is not fully understood, while in vitro research on chromatin compaction carried out for many deca...