Engineering nucleosomes for generating diverse chromatin assemblies

• Main Authors: Adhireksan, Zenita, Sharma, Deepti, Lee, Phoi Leng, Bao, Qiuye, Padavattan, Sivaraman, Shum, Wayne K., Davey, Gabriela Elzbieta, Davey, Curtis Alexander
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Chromatin Fibre; Nucleosome
• Online Access: https://hdl.handle.net/10356/147576
• Institution: Nanyang Technological University

Structural characterization of chromatin is challenging due to conformational and compositional heterogeneity in vivo and dynamic properties that limit achievable resolution in vitro. Although the maximum resolution for solving structures of large macromolecular assemblies by electron microscopy has...