Interferometer-in-spectrometer for high-resolution optical coherence tomography

Ultrahigh-resolution optical coherence tomography provides an axial resolution of 1-2 μm for resolving cellular structures of biological tissues critical for the diagnosis of diseases. However, it requires a relatively large spectral bandwidth which is not supported by the key components of the imag...

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Main Authors: Liu, Lishuang, Xie, Jun, Liu, Linbo, Chen, Si
Other Authors: School of Electrical and Electronic Engineering
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/147605
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1476052021-04-13T08:47:31Z Interferometer-in-spectrometer for high-resolution optical coherence tomography Liu, Lishuang Xie, Jun Liu, Linbo Chen, Si School of Electrical and Electronic Engineering School of Chemical and Biomedical Engineering Engineering::Electrical and electronic engineering Optical Coherence Tomography Spectral Bandwidth Ultrahigh-resolution optical coherence tomography provides an axial resolution of 1-2 μm for resolving cellular structures of biological tissues critical for the diagnosis of diseases. However, it requires a relatively large spectral bandwidth which is not supported by the key components of the imaging system. We propose a novel spectral-domain OCT design, termed interferometer-in-spectrometer, which is able to compensate the bandwidth limitations of the grating and the line scan sensor by spectral shaping without compromising the signal intensity and adding the system cost. The advantage of axial resolution and ranging depth over the standard design is experimentally validated using the standard testing method and fresh swine cornea ex vivo. Moreover, opportunities that opened up by this new scheme for improving the performances of spectral-domain OCT are also discussed. Published version 2021-04-13T08:47:31Z 2021-04-13T08:47:31Z 2020 Journal Article Liu, L., Xie, J., Liu, L. & Chen, S. (2020). Interferometer-in-spectrometer for high-resolution optical coherence tomography. Journal of Sensors, 2020. https://dx.doi.org/10.1155/2020/2530257 1687-725X 0000-0002-7465-0861 0000-0002-4683-9130 https://hdl.handle.net/10356/147605 10.1155/2020/2530257 2-s2.0-85078022595 2020 en Journal of Sensors © 2020 The Author(s). This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Electrical and electronic engineering
Optical Coherence Tomography
Spectral Bandwidth
spellingShingle Engineering::Electrical and electronic engineering
Optical Coherence Tomography
Spectral Bandwidth
Liu, Lishuang
Xie, Jun
Liu, Linbo
Chen, Si
Interferometer-in-spectrometer for high-resolution optical coherence tomography
description Ultrahigh-resolution optical coherence tomography provides an axial resolution of 1-2 μm for resolving cellular structures of biological tissues critical for the diagnosis of diseases. However, it requires a relatively large spectral bandwidth which is not supported by the key components of the imaging system. We propose a novel spectral-domain OCT design, termed interferometer-in-spectrometer, which is able to compensate the bandwidth limitations of the grating and the line scan sensor by spectral shaping without compromising the signal intensity and adding the system cost. The advantage of axial resolution and ranging depth over the standard design is experimentally validated using the standard testing method and fresh swine cornea ex vivo. Moreover, opportunities that opened up by this new scheme for improving the performances of spectral-domain OCT are also discussed.
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
Liu, Lishuang
Xie, Jun
Liu, Linbo
Chen, Si
format Article
author Liu, Lishuang
Xie, Jun
Liu, Linbo
Chen, Si
author_sort Liu, Lishuang
title Interferometer-in-spectrometer for high-resolution optical coherence tomography
title_short Interferometer-in-spectrometer for high-resolution optical coherence tomography
title_full Interferometer-in-spectrometer for high-resolution optical coherence tomography
title_fullStr Interferometer-in-spectrometer for high-resolution optical coherence tomography
title_full_unstemmed Interferometer-in-spectrometer for high-resolution optical coherence tomography
title_sort interferometer-in-spectrometer for high-resolution optical coherence tomography
publishDate 2021
url https://hdl.handle.net/10356/147605
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