Carbene-catalyzed enantioselective aldol reaction : post-aldol stereochemistry control and formation of quaternary stereogenic centers

• Main Authors: Yang, Xing, Majhi, Pankaj Kumar, Chai, Huifang, Liu, Bin, Sun, Jun, Liu, Ting, Liu, Yonggui, Zhou, Liejin, Xu, Jun, Liu, Jiawei, Wang, Dongdong, Zhao, Yanli, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Acylation; Aldol Reaction
• Online Access: https://hdl.handle.net/10356/148221
• Institution: Nanyang Technological University

The dominated approaches for asymmetric aldol reactions have primarily focused on the aldol carbon-carbon bond-forming events. Here we postulate and develop a new catalytic strategy that seeks to modulate the reaction thermodynamics and control the product enantioselectivities via post-aldol process...