Carbene-catalyzed alkylation of carboxylic esters via direct photoexcitation of acyl azolium intermediates

• Main Authors: Ren, Shi-Cao, Lv, Wen-Xin, Yang, Xing, Yan, Jia-Lei, Xu, Jun, Wang, Fang-Xin, Hao, Lin, Chai, Huifang, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science; N-heterocyclic Carbene; Acyl Azolium
• Online Access: https://hdl.handle.net/10356/148223
• Institution: Nanyang Technological University

A carbene-catalyzed reductive coupling reaction of carboxylic esters and substituted Hantzsch esters is disclosed. Key steps of this reaction include one-electron reduction of a carbene catalyst-bound acyl azolium intermediate to generate the corresponding radical intermediate for subsequent alkylat...