NHC-catalyzed covalent activation of heteroatoms for enantioselective reactions
Covalent activation of heteroatoms enabled by N-heterocyclic carbene (NHC) organic catalysts for enantioselective reactions is evaluated and summarized in this review. To date, sulfur, oxygen, and nitrogen atoms can be activated in this manner to react with another substrate to construct chiral c...
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| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/148224 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Covalent activation of heteroatoms enabled by N-heterocyclic carbene (NHC) organic catalysts for
enantioselective reactions is evaluated and summarized in this review. To date, sulfur, oxygen, and
nitrogen atoms can be activated in this manner to react with another substrate to construct chiral
carbon–heteroatom bonds with high optical enantioselectivities. The activation starts with addition of an
NHC catalyst to the carbonyl moiety (aldehyde or imine) of substrates that contain heteroatoms. The key
in this approach is the formation of intermediates covalently bound to the NHC catalyst, in which the
heteroatom of the substrate is activated as a nucleophilic reactive site. |
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