Enantioselective modification of sulfonamides and sulfonamide-containing drugs via carbene organic catalysis

• Main Authors: Song, Runjiang, Liu, Yingguo, Majhi, Pankaj Kumar, Ng, Pei Rou, Hao, Lin, Xu, Jun, Tian, Weiyi, Zhang, Long, Liu, Hongmei, Zhang, Xinglong, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Sulfonamides; Non-covalent Interactions
• Online Access: https://hdl.handle.net/10356/148228
• Institution: Nanyang Technological University

A carbene-catalyzed method for highly enantioselective modification of sulfonamides is disclosed. The reaction proceeds under mild conditions with broad substrate scope, wide functional group tolerance, and good to excellent yields. When multiple sulfonamides or amines are present in the same molecu...