Enantioselective modification of sulfonamides and sulfonamide-containing drugs via carbene organic catalysis

• المؤلفون الرئيسيون: Song, Runjiang, Liu, Yingguo, Majhi, Pankaj Kumar, Ng, Pei Rou, Hao, Lin, Xu, Jun, Tian, Weiyi, Zhang, Long, Liu, Hongmei, Zhang, Xinglong, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Chemistry; Sulfonamides; Non-covalent Interactions
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/148228
• المؤسسة: Nanyang Technological University

A carbene-catalyzed method for highly enantioselective modification of sulfonamides is disclosed. The reaction proceeds under mild conditions with broad substrate scope, wide functional group tolerance, and good to excellent yields. When multiple sulfonamides or amines are present in the same molecu...