Multi-compartment 3D-cultured organ-on-a-chip : towards a biomimetic Lymph Node for drug development

• Main Authors: Shanti, Aya, Samara, Bisan, Amal Abdullah, Hallfors, Nicholas, Accoto, Dino, Sapudom, Jiranuwat, Alatoom, Aseel, Teo, Jeremy, Danti, Serena, Stefanini, Cesare
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Mechanical engineering; Biomimicry; Drug Development
• Online Access: https://hdl.handle.net/10356/148594
• Institution: Nanyang Technological University

The interaction of immune cells with drugs and/or with other cell types should be mechanistically investigated in order to reduce attrition of new drug development. However, they are currently only limited technologies that address this need. In our work, we developed initial but significant buildin...