NHC-catalyzed cascade reaction between β-methyl enals and dienones for quick construction of complex multicyclic lactones

• Main Authors: Sun, Jun, Xu, Jun, Nie, Guihua, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Lactones; Molecules
• Online Access: https://hdl.handle.net/10356/148642
• Institution: Nanyang Technological University

A NHC-promoted cascade reaction between β-methyl enal and dienone is developed for quick access to multicyclic lactone molecules bearing quaternary chiral carbon centers. Our study constitutes the first 1,6-addition of the acylazolium vinyl enolate γ-carbon via NHC catalysis and provides rapid acces...