Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

• Main Authors: Zhou, Libin, Flores, Joseph, Noël, Anastasia, Beauchet, Olivier, Sjöström, P. Jesper, LeBlanc, Andrea C.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Alzheimer Disease; Axonal Degeneration
• Online Access: https://hdl.handle.net/10356/148649
• Institution: Nanyang Technological University

Activated Caspase-6 (Casp6) is associated with age-dependent cognitive impairment and Alzheimer disease (AD). Mice expressing human Caspase-6 in hippocampal CA1 neurons develop age-dependent cognitive deficits, neurodegeneration and neuroinflammation. This study assessed if methylene blue (MB), a ph...