Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay
Firefighters can be exposed to a complex set of contaminants while at a fire scene. Identifying new ways to monitor and assess exposure, particularly relating to toxicity is essential to determine the effectiveness of intervention techniques to reduce exposure. This study investigated the use of the...
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sg-ntu-dr.10356-1488602021-05-15T20:11:15Z Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay Beitel, Shawn C. Flahr, Leanne M. Hoppe-Jones, Christiane Burgess, Jefferey L. Littau, Sally R. Gulotta, John Moore, Paul Wallentine, Darin Snyder, Shane Allen Nanyang Environment and Water Research Institute Engineering::Environmental engineering::Hazardous substances Bioassay Polycyclic Aromatic Hydrocarbon Firefighters can be exposed to a complex set of contaminants while at a fire scene. Identifying new ways to monitor and assess exposure, particularly relating to toxicity is essential to determine the effectiveness of intervention techniques to reduce exposure. This study investigated the use of the polycyclic aromatic hydrocarbon (PAH) CALUX® bioassay for the assessment of exposure and associated toxicity firefighters might encounter. This was done through analysis of extracts of dermal wipes and urine samples collected from firefighters before and after a controlled fire. An increased bioassay response was observed from post-fire neck and calf samples, indicating a greater concentration of PAH-like compounds on the skin. The use of a baby wipe to clean the face and neck during rehab resulted in the attenuation of the observed bioassay response from the neck post-fire. Though a correlation was observed between the bioassay response and hydroxylated PAH concentrations found in the urine, the increased bioassay response from the post-fire urine samples was likely due to unknown compounds other than the hydroxylated PAHs tested. Our results suggest that this bioassay provides a useful measure of firefighter exposure, particularly relating to the potential toxicity of contaminants. Published version his study was funded by the Federal Emergency ManagementAgency,grantnumberEMW-2014-FP-00200. 2021-05-10T00:52:03Z 2021-05-10T00:52:03Z 2019 Journal Article Beitel, S. C., Flahr, L. M., Hoppe-Jones, C., Burgess, J. L., Littau, S. R., Gulotta, J., Moore, P., Wallentine, D. & Snyder, S. A. (2019). Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay. Environment International, 135, 105207--. https://dx.doi.org/10.1016/j.envint.2019.105207 0160-4120 https://hdl.handle.net/10356/148860 10.1016/j.envint.2019.105207 31812113 2-s2.0-85075869800 135 105207- en Environment International © 2019 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). application/pdf |
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Engineering::Environmental engineering::Hazardous substances Bioassay Polycyclic Aromatic Hydrocarbon Beitel, Shawn C. Flahr, Leanne M. Hoppe-Jones, Christiane Burgess, Jefferey L. Littau, Sally R. Gulotta, John Moore, Paul Wallentine, Darin Snyder, Shane Allen Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay |
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Firefighters can be exposed to a complex set of contaminants while at a fire scene. Identifying new ways to monitor and assess exposure, particularly relating to toxicity is essential to determine the effectiveness of intervention techniques to reduce exposure. This study investigated the use of the polycyclic aromatic hydrocarbon (PAH) CALUX® bioassay for the assessment of exposure and associated toxicity firefighters might encounter. This was done through analysis of extracts of dermal wipes and urine samples collected from firefighters before and after a controlled fire. An increased bioassay response was observed from post-fire neck and calf samples, indicating a greater concentration of PAH-like compounds on the skin. The use of a baby wipe to clean the face and neck during rehab resulted in the attenuation of the observed bioassay response from the neck post-fire. Though a correlation was observed between the bioassay response and hydroxylated PAH concentrations found in the urine, the increased bioassay response from the post-fire urine samples was likely due to unknown compounds other than the hydroxylated PAHs tested. Our results suggest that this bioassay provides a useful measure of firefighter exposure, particularly relating to the potential toxicity of contaminants. |
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Nanyang Environment and Water Research Institute |
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Nanyang Environment and Water Research Institute Beitel, Shawn C. Flahr, Leanne M. Hoppe-Jones, Christiane Burgess, Jefferey L. Littau, Sally R. Gulotta, John Moore, Paul Wallentine, Darin Snyder, Shane Allen |
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Article |
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Beitel, Shawn C. Flahr, Leanne M. Hoppe-Jones, Christiane Burgess, Jefferey L. Littau, Sally R. Gulotta, John Moore, Paul Wallentine, Darin Snyder, Shane Allen |
author_sort |
Beitel, Shawn C. |
title |
Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay |
title_short |
Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay |
title_full |
Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay |
title_fullStr |
Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay |
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Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay |
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assessment of the toxicity of firefighter exposures using the pah calux bioassay |
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2021 |
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https://hdl.handle.net/10356/148860 |
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1701270581247213568 |