Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load
Background: Periventricular leukoaraiosis may be an important pathological change in postural instability gait disorder (PIGD), a motor subtype of Parkinson's disease (PD). Clinical diagnosis of PIGD may be challenging for the general neurologist. Purpose: To evaluate 1) the utility of a f...
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sg-ntu-dr.10356-1489042023-03-05T15:35:19Z Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load Fang, Eric Ann, Chu Ning Maréchal, Bénédicte Lim, Jie Xin Tan, Shawn Yan Zhi Li, Huihua Gan, Julian Tan, Eng King Chan, Ling Ling School of Social Sciences Social sciences::Psychology Parkinson's Disease Postural Instability Gait Disorder Background: Periventricular leukoaraiosis may be an important pathological change in postural instability gait disorder (PIGD), a motor subtype of Parkinson's disease (PD). Clinical diagnosis of PIGD may be challenging for the general neurologist. Purpose: To evaluate 1) the utility of a fully automated volume‐based morphometry (Vol‐BM) in characterizing imaging diagnostic markers in PD and PIGD, including, 2) novel deep gray nuclear lesion load (GMab), and 3) discriminatory performance of a Vol‐BM model construct in classifying the PIGD subtype. Published version 2021-05-10T05:35:58Z 2021-05-10T05:35:58Z 2019 Journal Article Fang, E., Ann, C. N., Maréchal, B., Lim, J. X., Tan, S. Y. Z., Li, H., Gan, J., Tan, E. K. & Chan, L. L. (2019). Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load. Journal of Magnetic Resonance Imaging, 51(3), 748-756. https://dx.doi.org/10.1002/jmri.26887 1053-1807 https://hdl.handle.net/10356/148904 10.1002/jmri.26887 31365182 2-s2.0-85070068697 3 51 748 756 en Journal of Magnetic Resonance Imaging © 2019 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc.on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. application/pdf |
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Social sciences::Psychology Parkinson's Disease Postural Instability Gait Disorder Fang, Eric Ann, Chu Ning Maréchal, Bénédicte Lim, Jie Xin Tan, Shawn Yan Zhi Li, Huihua Gan, Julian Tan, Eng King Chan, Ling Ling Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load |
| description |
Background:
Periventricular leukoaraiosis may be an important pathological change in postural instability gait disorder (PIGD), a motor subtype of Parkinson's disease (PD). Clinical diagnosis of PIGD may be challenging for the general neurologist.
Purpose:
To evaluate 1) the utility of a fully automated volume‐based morphometry (Vol‐BM) in characterizing imaging diagnostic markers in PD and PIGD, including, 2) novel deep gray nuclear lesion load (GMab), and 3) discriminatory performance of a Vol‐BM model construct in classifying the PIGD subtype. |
| author2 |
School of Social Sciences |
| author_facet |
School of Social Sciences Fang, Eric Ann, Chu Ning Maréchal, Bénédicte Lim, Jie Xin Tan, Shawn Yan Zhi Li, Huihua Gan, Julian Tan, Eng King Chan, Ling Ling |
| format |
Article |
| author |
Fang, Eric Ann, Chu Ning Maréchal, Bénédicte Lim, Jie Xin Tan, Shawn Yan Zhi Li, Huihua Gan, Julian Tan, Eng King Chan, Ling Ling |
| author_sort |
Fang, Eric |
| title |
Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load |
| title_short |
Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load |
| title_full |
Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load |
| title_fullStr |
Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load |
| title_full_unstemmed |
Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load |
| title_sort |
differentiating parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load |
| publishDate |
2021 |
| url |
https://hdl.handle.net/10356/148904 |
| _version_ |
1759858315806900224 |