G protein-coupled receptor kinase 2 regulates mitochondrial bioenergetics and impairs myostatin-mediated autophagy in muscle cells

• Main Authors: Manfredi, Leandro Henrique, Ang, Joshur, Peker, Nesibe, Dagda, Ruben K., McFarlane, Craig
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Autophagy; G Protein-coupled Receptor Kinase 2
• Online Access: https://hdl.handle.net/10356/149016
• Institution: Nanyang Technological University

G protein-coupled receptor kinase 2 (GRK2) is an important protein involved in β-adrenergic receptor desensitization. In addition, studies have shown GRK2 can modulate different metabolic processes in the cell. For instance, GRK2 has been recently shown to promote mitochondrial biogenesis and increa...