A subset of flavaglines inhibits KRAS nanoclustering and activation

A subset of flavaglines inhibits KRAS nanoclustering and activation

The RAS oncogenes are frequently mutated in human cancers and among the three isoforms (KRAS, HRAS and NRAS), KRAS is the most frequently mutated oncogene. Here, we demonstrate that a subset of flavaglines, a class of natural anti-tumour drugs and chemical ligands of prohibitins, inhibit RAS GTP loa...

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Main Authors: Yurugi, Hajime, Zhuang, Yinyin, Siddiqui, Farid A., Liang, Hong, Rosigkeit, Sebastian, Zeng, Yongpeng, Abou-Hamdan, Hussein, Bockamp, Ernesto, Zhou, Yong, Abankwa, Daniel, Zhao, Wenting, Désaubry, Laurent, Rajalingam, Krishnaraj
其他作者: School of Chemical and Biomedical Engineering
格式: Article
語言:English
出版: 2021
主題:
Engineering::Bioengineering
KRAS
Phospholipid
在線閱讀:https://hdl.handle.net/10356/149025
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機構: Nanyang Technological University
語言: English

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https://hdl.handle.net/10356/149025

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