Metformin alters human host responses to Mycobacterium tuberculosis in healthy subjects

• Main Authors: Lachmandas, Ekta, Eckold, Clare, Böhme, Julia, Koeken, Valerie A. C. M., Mardiana Marzuki, Blok, Bastiaan, Arts, Rob J. W., Chen, Jinmiao, Teng, Karen W. W., Ratter, Jacqueline, Smolders, Elise J., Van den Heuvel, Corina, Stienstra, Rinke, Dockrell, Hazel M., Newell, Evan, Netea, Mihai G., Singhal, Amit, Cliff, Jacqueline M., Van Crevel, Reinout
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Metformin; Tuberculosis
• Online Access: https://hdl.handle.net/10356/149037
• Institution: Nanyang Technological University

Background" Metformin, the most widely administered diabetes drug, has been proposed as a candidate adjunctive host-directed therapy for tuberculosis, but little is known about its effects on human host responses to Mycobacterium tuberculosis. Methods: We investigated in vitro and in vivo effe...