Differential coassembly of α1-GABAARs associated with epileptic encephalopathy

• Main Authors: Hannan, Saad, Affandi, Aida H. B., Minere, Marielle, Jones, Charlotte, Goh, Pollyanna, Warnes, Gary, Popp, Bernt, Trollmann, Regina, Nizetic, Dean, Smart, Trevor G.
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Medicine; α Subunit Variant; Epilepsy
• 在線閱讀: https://hdl.handle.net/10356/149060
• 機構: Nanyang Technological University

GABAA receptors (GABAARs) are profoundly important for controlling neuronal excitability. Spontaneous and familial mutations to these receptors feature prominently in excitability disorders and neurodevelopmental deficits following disruption to GABA-mediated inhibition. Recent genotyping of an indi...