Differential coassembly of α1-GABAARs associated with epileptic encephalopathy

• المؤلفون الرئيسيون: Hannan, Saad, Affandi, Aida H. B., Minere, Marielle, Jones, Charlotte, Goh, Pollyanna, Warnes, Gary, Popp, Bernt, Trollmann, Regina, Nizetic, Dean, Smart, Trevor G.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Medicine; α Subunit Variant; Epilepsy
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/149060
• المؤسسة: Nanyang Technological University

GABAA receptors (GABAARs) are profoundly important for controlling neuronal excitability. Spontaneous and familial mutations to these receptors feature prominently in excitability disorders and neurodevelopmental deficits following disruption to GABA-mediated inhibition. Recent genotyping of an indi...