Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells

• Main Authors: Kwek, Zheng Hua, Ganguly, Rakesh, Afreen, A. Mohamed, Koh, Wei Xiang, Leong, Weng Kee, Tan, Kelvin Yong Leng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Science::Chemistry::Inorganic chemistry; Benzaldehyde; Carboxylato
• Online Access: https://hdl.handle.net/10356/149237
• Institution: Nanyang Technological University

The activated cluster Os3(CO)10(CH3CN)2 (1) reacts readily with a number of carboxylated chalcones and benzaldehydes (2a−j) to afford products with the general formula Os3(CO)10(µ-H)(µ-O2CR) (3a–j). The structures of all the novel clusters have been characterized by IR and 1H NMR spectroscopy, as well as mass spectrometry and elemental analysis. Single-crystal X-ray diffraction analysis has also been carried out for one of the carboxylated chalcones and two of the derivatized clusters. The activity of some of the derivatized clusters against the ER+ breast carcinoma MCF-7 cancer cell line has also been evaluated.