Moving fast but going slow : coordination challenges for trials of COVID-19 post-exposure prophylaxis

An unprecedented volume of research has been generated in response to the COVID-19 pandemic. However, there are risks of inefficient duplication and of important work being impeded if efforts are not synchronized. Excessive reliance on observational studies, which can be more rapidly conducted but a...

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Main Authors: Tan, Darrell H. S., Agrawal, Rupesh, Barnabas, Ruanne V., Giles, Jon T., Dull, Peter
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/149366
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1493662023-07-14T16:01:04Z Moving fast but going slow : coordination challenges for trials of COVID-19 post-exposure prophylaxis Tan, Darrell H. S. Agrawal, Rupesh Barnabas, Ruanne V. Giles, Jon T. Dull, Peter School of Materials Science and Engineering Science::Medicine COVID-19 HCQ PEP Trial An unprecedented volume of research has been generated in response to the COVID-19 pandemic. However, there are risks of inefficient duplication and of important work being impeded if efforts are not synchronized. Excessive reliance on observational studies, which can be more rapidly conducted but are inevitably subject to measured and unmeasured confounders, can foil efforts to conduct rigorous randomized trials. These challenges are illustrated by recent global efforts to conduct clinical trials of post-exposure prophylaxis (PEP) as a strategy for preventing COVID-19. Innovative strategies are needed to help overcome these issues, including increasing communication between the Data Safety and Monitoring Committees (DSMCs) of similar trials. It is important to reinforce the primacy of high-quality trials in generating unbiased answers to pressing prevention and treatment questions about COVID-19. Published version DHST is supported by a Tier 2 Canada Research Chair in HIV Prevention and STI Research. 2021-07-28T06:53:52Z 2021-07-28T06:53:52Z 2020 Journal Article Tan, D. H. S., Agrawal, R., Barnabas, R. V., Giles, J. T. & Dull, P. (2020). Moving fast but going slow : coordination challenges for trials of COVID-19 post-exposure prophylaxis. Trials, 21(1). https://dx.doi.org/10.1186/s13063-020-04754-9 1745-6215 0000-0002-3069-2875 https://hdl.handle.net/10356/149366 10.1186/s13063-020-04754-9 32993804 2-s2.0-85092268326 1 21 en Trials © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
COVID-19
HCQ PEP Trial
spellingShingle Science::Medicine
COVID-19
HCQ PEP Trial
Tan, Darrell H. S.
Agrawal, Rupesh
Barnabas, Ruanne V.
Giles, Jon T.
Dull, Peter
Moving fast but going slow : coordination challenges for trials of COVID-19 post-exposure prophylaxis
description An unprecedented volume of research has been generated in response to the COVID-19 pandemic. However, there are risks of inefficient duplication and of important work being impeded if efforts are not synchronized. Excessive reliance on observational studies, which can be more rapidly conducted but are inevitably subject to measured and unmeasured confounders, can foil efforts to conduct rigorous randomized trials. These challenges are illustrated by recent global efforts to conduct clinical trials of post-exposure prophylaxis (PEP) as a strategy for preventing COVID-19. Innovative strategies are needed to help overcome these issues, including increasing communication between the Data Safety and Monitoring Committees (DSMCs) of similar trials. It is important to reinforce the primacy of high-quality trials in generating unbiased answers to pressing prevention and treatment questions about COVID-19.
author2 School of Materials Science and Engineering
author_facet School of Materials Science and Engineering
Tan, Darrell H. S.
Agrawal, Rupesh
Barnabas, Ruanne V.
Giles, Jon T.
Dull, Peter
format Article
author Tan, Darrell H. S.
Agrawal, Rupesh
Barnabas, Ruanne V.
Giles, Jon T.
Dull, Peter
author_sort Tan, Darrell H. S.
title Moving fast but going slow : coordination challenges for trials of COVID-19 post-exposure prophylaxis
title_short Moving fast but going slow : coordination challenges for trials of COVID-19 post-exposure prophylaxis
title_full Moving fast but going slow : coordination challenges for trials of COVID-19 post-exposure prophylaxis
title_fullStr Moving fast but going slow : coordination challenges for trials of COVID-19 post-exposure prophylaxis
title_full_unstemmed Moving fast but going slow : coordination challenges for trials of COVID-19 post-exposure prophylaxis
title_sort moving fast but going slow : coordination challenges for trials of covid-19 post-exposure prophylaxis
publishDate 2021
url https://hdl.handle.net/10356/149366
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