Modulators of rituximab-induced complement-dependent cytotoxicity in diffuse large B-cell lymphoma

• Main Author: Ong, Charmaine Zi Yan
• Other Authors: -
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2021
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/149717
• Institution: Nanyang Technological University

Rituximab, the chimeric monoclonal antibody targeting CD20, forms the cornerstone of therapy for diffuse large B-cell lymphoma (DLBCL). However, more than one-third of patients eventually become unresponsive or resistant to rituximab. Although the mechanisms of action and resistance are not well und...