Structure-guided design of immunomodulatory RNAs specifically targeting the cytoplasmic viral RNA sensor RIG-I

• Main Authors: Yong, Hui Yee, Zheng, Jie, Ho, Victor Chin Yong, Nguyen, Mai Trinh, Fink, Katja, Griffin, Patrick R., Luo, Dahai
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Immunomodulatory; RNAs
• Online Access: https://hdl.handle.net/10356/149909
• Institution: Nanyang Technological University

The cytoplasmic immune sensor RIG-I detects viral RNA and initiates an antiviral immune response upon activation. It has become a potential target for vaccination and immunotherapies. To develop the smallest but potent immunomodulatory RNA (immRNAs) species, we performed structure-guided RNA design...