Differences in optic nerve head blood flow regulation in normal tension glaucoma patients and healthy controls as assessed with laser speckle flowgraphy during the water drinking test

Précis: Optic nerve head (ONH) perfusion was not significantly altered in subjects with normal tension glaucoma (NTG) nor in healthy individuals after performing the water drinking test (WDT), because of its limited effect on ocular perfusion pressure (OPP). Purpose: ONH blood flow can be maintained...

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Main Authors: Mursch-Edlmayr, Anna S., Luft, Nikolaus, Podkowinski, Dominika, Ring, Michael, Schmetterer, Leopold, Bolz, Matthias
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/150049
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1500492021-06-04T03:36:46Z Differences in optic nerve head blood flow regulation in normal tension glaucoma patients and healthy controls as assessed with laser speckle flowgraphy during the water drinking test Mursch-Edlmayr, Anna S. Luft, Nikolaus Podkowinski, Dominika Ring, Michael Schmetterer, Leopold Bolz, Matthias Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Blood Flow Regulation Laser Speckle Flowgraphy Précis: Optic nerve head (ONH) perfusion was not significantly altered in subjects with normal tension glaucoma (NTG) nor in healthy individuals after performing the water drinking test (WDT), because of its limited effect on ocular perfusion pressure (OPP). Purpose: ONH blood flow can be maintained stable in healthy individuals because of a physiological phenomenon called autoregulation. Impairment of autoregulation has been shown especially under condition of NTG. The purpose of this study was to investigate the ONH blood flow autoregulation in patients with NTG by influencing the OPP with the WDT. Methods: The study included 9 eyes from 9 white patients with a diagnosis of NTG and 9 eyes from age-matched and sex-matched healthy individuals. In the glaucoma group, the antiglaucomatous therapy was paused 3 weeks before the investigations. Measurements of ONH blood flow were performed with laser speckle flowgraphy. After baseline measurements, individuals ingested 800 mL of water in <5 minutes. Measurements were repeated after 15, 30, and 45 minutes. Results: The water ingestion led to a significant rise in intraocular pressure (P<0.001) but also mean arterial pressure (P<0.001) in both groups. This resulted in stable OPP (P=0.051) with no significant difference between the groups (P=0.43). ONH blood flow remained stable over time in both groups (P=0.719). No significant interaction of time and group was shown for all parameters. Conclusions: Our findings show that the WDT does not significantly influence the OPP and therefore has to be considered inferior to other methods used to assess blood flow autoregulation. 2021-06-04T03:36:46Z 2021-06-04T03:36:46Z 2019 Journal Article Mursch-Edlmayr, A. S., Luft, N., Podkowinski, D., Ring, M., Schmetterer, L. & Bolz, M. (2019). Differences in optic nerve head blood flow regulation in normal tension glaucoma patients and healthy controls as assessed with laser speckle flowgraphy during the water drinking test. Journal of Glaucoma, 28(7), 649-654. https://dx.doi.org/10.1097/IJG.0000000000001258 1057-0829 https://hdl.handle.net/10356/150049 10.1097/IJG.0000000000001258 30950964 2-s2.0-85064191664 7 28 649 654 en Journal of Glaucoma © 2019 Wolters Kluwer Health, Inc. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Blood Flow Regulation
Laser Speckle Flowgraphy
spellingShingle Science::Medicine
Blood Flow Regulation
Laser Speckle Flowgraphy
Mursch-Edlmayr, Anna S.
Luft, Nikolaus
Podkowinski, Dominika
Ring, Michael
Schmetterer, Leopold
Bolz, Matthias
Differences in optic nerve head blood flow regulation in normal tension glaucoma patients and healthy controls as assessed with laser speckle flowgraphy during the water drinking test
description Précis: Optic nerve head (ONH) perfusion was not significantly altered in subjects with normal tension glaucoma (NTG) nor in healthy individuals after performing the water drinking test (WDT), because of its limited effect on ocular perfusion pressure (OPP). Purpose: ONH blood flow can be maintained stable in healthy individuals because of a physiological phenomenon called autoregulation. Impairment of autoregulation has been shown especially under condition of NTG. The purpose of this study was to investigate the ONH blood flow autoregulation in patients with NTG by influencing the OPP with the WDT. Methods: The study included 9 eyes from 9 white patients with a diagnosis of NTG and 9 eyes from age-matched and sex-matched healthy individuals. In the glaucoma group, the antiglaucomatous therapy was paused 3 weeks before the investigations. Measurements of ONH blood flow were performed with laser speckle flowgraphy. After baseline measurements, individuals ingested 800 mL of water in <5 minutes. Measurements were repeated after 15, 30, and 45 minutes. Results: The water ingestion led to a significant rise in intraocular pressure (P<0.001) but also mean arterial pressure (P<0.001) in both groups. This resulted in stable OPP (P=0.051) with no significant difference between the groups (P=0.43). ONH blood flow remained stable over time in both groups (P=0.719). No significant interaction of time and group was shown for all parameters. Conclusions: Our findings show that the WDT does not significantly influence the OPP and therefore has to be considered inferior to other methods used to assess blood flow autoregulation.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Mursch-Edlmayr, Anna S.
Luft, Nikolaus
Podkowinski, Dominika
Ring, Michael
Schmetterer, Leopold
Bolz, Matthias
format Article
author Mursch-Edlmayr, Anna S.
Luft, Nikolaus
Podkowinski, Dominika
Ring, Michael
Schmetterer, Leopold
Bolz, Matthias
author_sort Mursch-Edlmayr, Anna S.
title Differences in optic nerve head blood flow regulation in normal tension glaucoma patients and healthy controls as assessed with laser speckle flowgraphy during the water drinking test
title_short Differences in optic nerve head blood flow regulation in normal tension glaucoma patients and healthy controls as assessed with laser speckle flowgraphy during the water drinking test
title_full Differences in optic nerve head blood flow regulation in normal tension glaucoma patients and healthy controls as assessed with laser speckle flowgraphy during the water drinking test
title_fullStr Differences in optic nerve head blood flow regulation in normal tension glaucoma patients and healthy controls as assessed with laser speckle flowgraphy during the water drinking test
title_full_unstemmed Differences in optic nerve head blood flow regulation in normal tension glaucoma patients and healthy controls as assessed with laser speckle flowgraphy during the water drinking test
title_sort differences in optic nerve head blood flow regulation in normal tension glaucoma patients and healthy controls as assessed with laser speckle flowgraphy during the water drinking test
publishDate 2021
url https://hdl.handle.net/10356/150049
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