Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects

Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signa...

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Main Authors: Wiraja, Christian, Yeo, David Chenloong, Lio, Daniel Chin Shiuan, Zheng, Mengjia, Xu, Chenjie
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/150637
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1506372021-06-07T08:33:07Z Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects Wiraja, Christian Yeo, David Chenloong Lio, Daniel Chin Shiuan Zheng, Mengjia Xu, Chenjie School of Chemical and Biomedical Engineering NTU-Northwestern Institute for Nanomedicine Engineering::Chemical engineering Activatable Probes Biosensors Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications. Agency for Science, Technology and Research (A*STAR) Nanyang Technological University This work was supported by the NTU-Northwestern Institute for Nanomedicine and Singapore A*STAR Biomedical Research Council (IAF-PP grant). 2021-06-07T08:33:07Z 2021-06-07T08:33:07Z 2019 Journal Article Wiraja, C., Yeo, D. C., Lio, D. C. S., Zheng, M. & Xu, C. (2019). Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects. ChemBioChem, 20(4), 437-450. https://dx.doi.org/10.1002/cbic.201800430 1439-4227 0000-0002-8278-3912 https://hdl.handle.net/10356/150637 10.1002/cbic.201800430 30230165 2-s2.0-85056833915 4 20 437 450 en ChemBioChem © 2019 Wiley-VCH Verlag GmbH &Co. KGaA, Weinhei. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Chemical engineering
Activatable Probes
Biosensors
spellingShingle Engineering::Chemical engineering
Activatable Probes
Biosensors
Wiraja, Christian
Yeo, David Chenloong
Lio, Daniel Chin Shiuan
Zheng, Mengjia
Xu, Chenjie
Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects
description Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Wiraja, Christian
Yeo, David Chenloong
Lio, Daniel Chin Shiuan
Zheng, Mengjia
Xu, Chenjie
format Article
author Wiraja, Christian
Yeo, David Chenloong
Lio, Daniel Chin Shiuan
Zheng, Mengjia
Xu, Chenjie
author_sort Wiraja, Christian
title Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects
title_short Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects
title_full Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects
title_fullStr Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects
title_full_unstemmed Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects
title_sort functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects
publishDate 2021
url https://hdl.handle.net/10356/150637
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