Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects
Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signa...
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sg-ntu-dr.10356-1506372021-06-07T08:33:07Z Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects Wiraja, Christian Yeo, David Chenloong Lio, Daniel Chin Shiuan Zheng, Mengjia Xu, Chenjie School of Chemical and Biomedical Engineering NTU-Northwestern Institute for Nanomedicine Engineering::Chemical engineering Activatable Probes Biosensors Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications. Agency for Science, Technology and Research (A*STAR) Nanyang Technological University This work was supported by the NTU-Northwestern Institute for Nanomedicine and Singapore A*STAR Biomedical Research Council (IAF-PP grant). 2021-06-07T08:33:07Z 2021-06-07T08:33:07Z 2019 Journal Article Wiraja, C., Yeo, D. C., Lio, D. C. S., Zheng, M. & Xu, C. (2019). Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects. ChemBioChem, 20(4), 437-450. https://dx.doi.org/10.1002/cbic.201800430 1439-4227 0000-0002-8278-3912 https://hdl.handle.net/10356/150637 10.1002/cbic.201800430 30230165 2-s2.0-85056833915 4 20 437 450 en ChemBioChem © 2019 Wiley-VCH Verlag GmbH &Co. KGaA, Weinhei. All rights reserved. |
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Engineering::Chemical engineering Activatable Probes Biosensors Wiraja, Christian Yeo, David Chenloong Lio, Daniel Chin Shiuan Zheng, Mengjia Xu, Chenjie Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects |
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Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Wiraja, Christian Yeo, David Chenloong Lio, Daniel Chin Shiuan Zheng, Mengjia Xu, Chenjie |
format |
Article |
author |
Wiraja, Christian Yeo, David Chenloong Lio, Daniel Chin Shiuan Zheng, Mengjia Xu, Chenjie |
author_sort |
Wiraja, Christian |
title |
Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects |
title_short |
Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects |
title_full |
Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects |
title_fullStr |
Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects |
title_full_unstemmed |
Functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects |
title_sort |
functional imaging with nucleic-acid-based sensors : technology, application and future healthcare prospects |
publishDate |
2021 |
url |
https://hdl.handle.net/10356/150637 |
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1702431249271881728 |