Vitamin D modulates human macrophage response to Mycobacterium tuberculosis DNA

• Main Authors: Cervantes, Jorge L., Oak, Esther, Garcia, John, Liu, Hongfei, Lorenzini, Paolo A., Batra, Deepika, Chhabra, Arvind, Salazar, Juan C., Roca, Xavier
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Mycobacterium Tuberculosis; Type I IFNs
• Online Access: https://hdl.handle.net/10356/150639
• Institution: Nanyang Technological University

Mycobacterium tuberculosis (Mtb) is a facultative intracellular pathogen that infects macrophages where it avoids elimination by interfering with host defense mechanisms, including phago-lysosome fusion. Endosomal Toll-like receptors (TLRs) generate Type I Interferons (IFNs), which are associated wi...