Evaluation of ferrocenyl phosphines as potent antimalarials targeting the digestive vacuole function of Plasmodium falciparum

• Main Authors: Subramanian, Gowtham, Abdul Sadeer, Mukherjee, Kalyani, Kojima, Tadayuki, Tripathi, Pallavi, Naidu, Renugah, Tay, Shan Wen, Pang, Jia Hao, Pullarkat, Sumod A., Chandramohanadas, Rajesh
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; In-vitro; Hemoglobin Degradation
• Online Access: https://hdl.handle.net/10356/150653
• Institution: Nanyang Technological University

Owing to their lipophilic nature and chemical stability, ferrocene and its derivatives have been widely explored as antimicrobial agents, in combination with other active chemical 'war heads'. A prime example is ferroquine, an analogue of chloroquine obtained by covalently bonding ferrocen...