DNA binding and cleavage modes of shishijimicin A

DNA binding and cleavage modes of shishijimicin A

Although shishijimicin A and its extreme potencies against an array of cancer cell lines have been known for more than a decade, its assumed DNA-cleaving mechanism has not been substantiated as yet. Herein we report studies that reveal binding and scission of double-stranded DNA by shishijimicin A....

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Bibliographic Details
Main Authors: Zhang, Hao, Li, Ruofan, Ba, Sai, Lu, Zhaoyong, Pitsinos, Emmanuel N., Li, Tianhu, Nicolaou, K. C.
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Chemistry
Electrophoresis
Crystal Cleavage
Online Access:https://hdl.handle.net/10356/150952
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/150952

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