Micromotor-assisted human serum glucose biosensing
Artificial self-propelled micromachines have shown great promise in biomedical sciences. In this work, we use Mg/Pt Janus micromotors with self-rejuvenating surfaces to enhance the electrochemical sensing performance and sensitivity toward glucose in human serum. The detection of glucose is based on...
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sg-ntu-dr.10356-1509882021-06-01T05:13:02Z Micromotor-assisted human serum glucose biosensing Kong, Lei Rohaizad, Nasuha Muhammad Zafir Mohamad Nasir Guan, Jianguo Pumera, Martin School of Physical and Mathematical Sciences Interdisciplinary Graduate School (IGS) NTU Institute for Health Technologies Science::Chemistry Janus Micromotors Driven Artificial self-propelled micromachines have shown great promise in biomedical sciences. In this work, we use Mg/Pt Janus micromotors with self-rejuvenating surfaces to enhance the electrochemical sensing performance and sensitivity toward glucose in human serum. The detection of glucose is based on the glucose oxidase enzyme and ferrocenemethanol shuttle system, where mass transfer was dramatically enhanced by the rapid motion of Mg/Pt Janus micromotors. The obtained chronoamperometric data show that Mg/Pt Janus micromotors play a synergistic role in enhancing the current response at millimolar concentrations of glucose in human serum. The current signals increased with the corresponding increase in amount of micromotors introduced. Furthermore, a linear relationship between current signal and glucose concentration was established, while the limit of detection improved when mobile Mg/Pt Janus micromachines were used. Glucose detection enhanced by micromachines may pave the way for their future applications in biomedicine and medical diagnostic devices. Agency for Science, Technology and Research (A*STAR) This work was supported by the project Advanced Functional Nanorobots (reg. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). The authors acknowledge A*STAR Grant SERC A1783c0005 (Singapore). L.K. acknowledges the Scholarship Fund from the China Scholarship Council (CSC). 2021-06-01T05:13:02Z 2021-06-01T05:13:02Z 2019 Journal Article Kong, L., Rohaizad, N., Muhammad Zafir Mohamad Nasir, Guan, J. & Pumera, M. (2019). Micromotor-assisted human serum glucose biosensing. Analytical Chemistry, 91(9), 5660-5666. https://dx.doi.org/10.1021/acs.analchem.8b05464 0003-2700 0000-0002-2223-4524 0000-0001-5846-2951 https://hdl.handle.net/10356/150988 10.1021/acs.analchem.8b05464 30986039 2-s2.0-85064969484 9 91 5660 5666 en SERC A1783c0005 Analytical Chemistry © 2019 American Chemical Society. All rights reserved. |
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Science::Chemistry Janus Micromotors Driven Kong, Lei Rohaizad, Nasuha Muhammad Zafir Mohamad Nasir Guan, Jianguo Pumera, Martin Micromotor-assisted human serum glucose biosensing |
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Artificial self-propelled micromachines have shown great promise in biomedical sciences. In this work, we use Mg/Pt Janus micromotors with self-rejuvenating surfaces to enhance the electrochemical sensing performance and sensitivity toward glucose in human serum. The detection of glucose is based on the glucose oxidase enzyme and ferrocenemethanol shuttle system, where mass transfer was dramatically enhanced by the rapid motion of Mg/Pt Janus micromotors. The obtained chronoamperometric data show that Mg/Pt Janus micromotors play a synergistic role in enhancing the current response at millimolar concentrations of glucose in human serum. The current signals increased with the corresponding increase in amount of micromotors introduced. Furthermore, a linear relationship between current signal and glucose concentration was established, while the limit of detection improved when mobile Mg/Pt Janus micromachines were used. Glucose detection enhanced by micromachines may pave the way for their future applications in biomedicine and medical diagnostic devices. |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Kong, Lei Rohaizad, Nasuha Muhammad Zafir Mohamad Nasir Guan, Jianguo Pumera, Martin |
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Article |
author |
Kong, Lei Rohaizad, Nasuha Muhammad Zafir Mohamad Nasir Guan, Jianguo Pumera, Martin |
author_sort |
Kong, Lei |
title |
Micromotor-assisted human serum glucose biosensing |
title_short |
Micromotor-assisted human serum glucose biosensing |
title_full |
Micromotor-assisted human serum glucose biosensing |
title_fullStr |
Micromotor-assisted human serum glucose biosensing |
title_full_unstemmed |
Micromotor-assisted human serum glucose biosensing |
title_sort |
micromotor-assisted human serum glucose biosensing |
publishDate |
2021 |
url |
https://hdl.handle.net/10356/150988 |
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1702431198172676096 |