Microneedle-assisted topical delivery of photodynamically active mesoporous formulation for combination therapy of deep-seated melanoma

• Main Authors: Tham, Phoebe Huijun, Xu, Keming, Lim, Wei Qi, Chen, Hongzhong, Zheng, Mengjia, Thng, Steven Tien Guan, Venkatraman, Subbu S., Xu, Chenjie, Zhao, Yanli
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Combination Therapy; Mesoporous Formulation
• Online Access: https://hdl.handle.net/10356/151179
• Institution: Nanyang Technological University

Topical treatment using photodynamic therapy (PDT) for many types of skin cancers has largely been limited by the inability of existing photosensitizers to penetrate into the deep skin tissue. To overcome these problems, we developed a mesoporous nanovehicle with dual loading of photosensitizers and...