High-intensity focused ultrasound ablation by the dual-frequency excitation

High-intensity focused ultrasound (HIFU) has emerged as an effective and noninvasive therapeutic modality for cancer and solid tumor. Despite its promising clinical outcomes and the approval of the Food and Drug Administration of many countries, the ablation time of a large target is long, so enhanc...

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Main Authors: Law, Berlinda Siu Kwun, Zhou, Yufeng
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/151219
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1512192021-07-02T03:33:24Z High-intensity focused ultrasound ablation by the dual-frequency excitation Law, Berlinda Siu Kwun Zhou, Yufeng School of Mechanical and Aerospace Engineering Engineering::Mechanical engineering Cavitation Dual-frequency Excitation High-intensity focused ultrasound (HIFU) has emerged as an effective and noninvasive therapeutic modality for cancer and solid tumor. Despite its promising clinical outcomes and the approval of the Food and Drug Administration of many countries, the ablation time of a large target is long, so enhancement of the lesion production is highly desired. In this study, dual-frequency (or amplitude modulation) excitation was evaluated both numerically and experimentally, and its performance was compared with that using single-frequency excitation at the same power output. The nonlinear wave propagation model was used to simulate the acoustic field of HIFU exposure, the Gilmore model was used to determine the induced bubble dynamics, and then absorbed acoustic energy and bubble-enhanced heating were put into the BioHeat equation to calculate the temperature elevation. HIFU-produced lesion in the bovine serum albumin-embedded polyacrylamide was recorded photographically. It is found that dual-frequency excitation (3.16 + 3.20MHz) can increase the lesion area by 35%-65% compared to single-frequency excitation (3.18 MHz) at the same power output. The lesion enhancement increases with the pulse repetition frequency, duty cycle, and modulation depth and decreases with the frequency difference. In summary, dual-frequency excitation can increase the bubble cavitation and the associated heating for HIFU ablation for large lesion production. The authors would like to thank Y. Lei for the help of numerical simulation and experiment. 2021-07-02T03:33:24Z 2021-07-02T03:33:24Z 2018 Journal Article Law, B. S. K. & Zhou, Y. (2018). High-intensity focused ultrasound ablation by the dual-frequency excitation. IEEE Transactions On Ultrasonics, Ferroelectrics, and Frequency Control, 66(1), 18-25. https://dx.doi.org/10.1109/TUFFC.2018.2876331 0885-3010 0000-0003-4086-2150 https://hdl.handle.net/10356/151219 10.1109/TUFFC.2018.2876331 30334792 2-s2.0-85060319703 1 66 18 25 en IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control © 2018 IEEE. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Mechanical engineering
Cavitation
Dual-frequency Excitation
spellingShingle Engineering::Mechanical engineering
Cavitation
Dual-frequency Excitation
Law, Berlinda Siu Kwun
Zhou, Yufeng
High-intensity focused ultrasound ablation by the dual-frequency excitation
description High-intensity focused ultrasound (HIFU) has emerged as an effective and noninvasive therapeutic modality for cancer and solid tumor. Despite its promising clinical outcomes and the approval of the Food and Drug Administration of many countries, the ablation time of a large target is long, so enhancement of the lesion production is highly desired. In this study, dual-frequency (or amplitude modulation) excitation was evaluated both numerically and experimentally, and its performance was compared with that using single-frequency excitation at the same power output. The nonlinear wave propagation model was used to simulate the acoustic field of HIFU exposure, the Gilmore model was used to determine the induced bubble dynamics, and then absorbed acoustic energy and bubble-enhanced heating were put into the BioHeat equation to calculate the temperature elevation. HIFU-produced lesion in the bovine serum albumin-embedded polyacrylamide was recorded photographically. It is found that dual-frequency excitation (3.16 + 3.20MHz) can increase the lesion area by 35%-65% compared to single-frequency excitation (3.18 MHz) at the same power output. The lesion enhancement increases with the pulse repetition frequency, duty cycle, and modulation depth and decreases with the frequency difference. In summary, dual-frequency excitation can increase the bubble cavitation and the associated heating for HIFU ablation for large lesion production.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Law, Berlinda Siu Kwun
Zhou, Yufeng
format Article
author Law, Berlinda Siu Kwun
Zhou, Yufeng
author_sort Law, Berlinda Siu Kwun
title High-intensity focused ultrasound ablation by the dual-frequency excitation
title_short High-intensity focused ultrasound ablation by the dual-frequency excitation
title_full High-intensity focused ultrasound ablation by the dual-frequency excitation
title_fullStr High-intensity focused ultrasound ablation by the dual-frequency excitation
title_full_unstemmed High-intensity focused ultrasound ablation by the dual-frequency excitation
title_sort high-intensity focused ultrasound ablation by the dual-frequency excitation
publishDate 2021
url https://hdl.handle.net/10356/151219
_version_ 1705151336930082816