A new role for Drosophila Aurora-A in maintaining chromosome integrity

• Main Authors: Merigliano, Chiara, Mascolo, Elisa, Cesta, Anthony, Saggio, Isabella, Vernì, Fiammetta
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Aurora-A; Chromosome Aberrations
• Online Access: https://hdl.handle.net/10356/151271
• Institution: Nanyang Technological University

Aurora-A is a conserved mitotic kinase overexpressed in many types of cancer. Growing evidence shows that Aurora-A plays a crucial role in DNA damage response (DDR) although this aspect has been less characterized. We isolated a new aur-A mutation, named aur-A949, in Drosophila, and we showed that i...