Multiplex targeted mass spectrometry assay for one-shot flavivirus diagnosis

• Main Authors: Wee, Sheena, Alli-Shaik, Asfa, Kek, Relus, Swa, Hannah L. F., Tien, Wei-Ping, Lim, Vanessa W., Leo, Yee-Sin, Ng, Lee-Ching, Hapuarachchi, Hapuarachchige C., Gunaratne, Jayantha
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Targeted Proteomics; Parallel Reaction Monitoring
• Online Access: https://hdl.handle.net/10356/151418
• Institution: Nanyang Technological University

Targeted proteomic mass spectrometry is emerging as a salient clinical diagnostic tool to track protein biomarkers. However, its strong analytical properties have not been exploited in the diagnosis and typing of flaviviruses. Here, we report the development of a sensitive and specific single-shot r...