Minimally invasive electroceutical catheter for endoluminal defect sealing

• Main Authors: Singh, Manisha, Varela, Claudia E., Whyte, William, Horvath, Markus A., Tan, Nigel C. S., Ong, Chee Bing, Liang, Patric, Schermerhorn, Marc L., Roche, Ellen T., Steele, Terry W. J.
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Bioengineering; Engineering::Materials; Adhesives; Catheters
• Online Access: https://hdl.handle.net/10356/151449
• Institution: Nanyang Technological University

Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally-invasive deployment. Voltage-activated tissue adhesives offer a new strategy for endoluminal repair. To facilitate the clinical translation of voltage-activated adhesives, an electroceutical patch (ePATCH) paired with a minimally-invasive catheter with retractable electrodes (CATRE) is challenged against the repair of in-vivo and ex-vivo lumen defects. The ePATCH/CATRE platform demonstrates the sealing of lumen defects up to 2 mm in diameter on wet tissue substrates. Water-tight seals are flexible and resilient, withstanding over 20,000 physiological relevant stress/strain cycles. No disruption to electrical signals was observed when the ePATCH was electrically activated on the beating heart. The ePATCH/CATRE platform has diverse potential applications ranging from endovascular treatment of pseudoaneurysms/fistulae to bioelectrodes towards electrophysiological mapping.