An enantioconvergent halogenophilic nucleophilic substitution (SN2X) reaction

• Main Authors: Zhang, Xin, Ren, Jingyun, Tan, Siu Min, Tan, Davin, Lee, Richmond, Tan, Choon-Hong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Phase-transfer; Basis-sets
• Online Access: https://hdl.handle.net/10356/151604
• Institution: Nanyang Technological University

Bimolecular nucleophilic substitution (SN2) plays a central role in organic chemistry. In the conventionally accepted mechanism, the nucleophile displaces a carbon-bound leaving group X, often a halogen, by attacking the carbon face opposite the C–X bond. A less common variant, the halogenophilic SN...