Biodegradable polymers as a noncoding miRNA nanocarrier for multiple targeting therapy of human hepatocellular carcinoma

• Main Authors: Yang, Chengbin, Yin, Ming-jie, Xu, Gaixia, Lin, Wei-Jen, Chen, Jiajie, Zhang, Yinling, Feng, Tao, Huang, Peng, Chen, Chih-Kuang, Yong, Ken-Tye
• Other Authors: School of Electrical and Electronic Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Electrical and electronic engineering; Biodegradable; Hepatocellular Carcinoma
• Online Access: https://hdl.handle.net/10356/151662
• Institution: Nanyang Technological University

Therapeutic strategy based on the restoration of tumor suppressor-microRNAs (miRNAs) is a promising approach for cancer therapy, but the low delivery efficiency of miRNA remains a huge hurdle due to the lack of safe and efficient nonviral carriers. In this work, with the use of newly developed PEGyl...