Methicillin-resistant Staphylococcus aureus colonisation : epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore
Current knowledge of methicillin-resistant Staphylococcus aureus (MRSA) colonisation in relation to epidemiological characteristics is incomplete. We conducted a cross-sectional study at an acute-care tertiary infectious diseases hospital of MRSA isolates identified through routine surveillance from...
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sg-ntu-dr.10356-1516682021-07-14T07:13:24Z Methicillin-resistant Staphylococcus aureus colonisation : epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore Htun, Htet Lin Kyaw, Win Mar de Sessions, Paola Flórez Low, Louie Hibberd, Martin Lloyd Chow, Angela Leo, Yee Sin Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Epidemiology Hospital Microbiology Current knowledge of methicillin-resistant Staphylococcus aureus (MRSA) colonisation in relation to epidemiological characteristics is incomplete. We conducted a cross-sectional study at an acute-care tertiary infectious diseases hospital of MRSA isolates identified through routine surveillance from January 2009 to December 2011. We randomly selected 205 MRSA isolates (119 inpatients) from 798 isolates (427 inpatients) for molecular profiling using multilocus sequence typing. Multilevel multinomial logistic regression was used to estimate odds ratio (OR) assessing the predilection of MRSA strains for anatomic sites, and associations of strains with human immunodeficiency virus (HIV) infection. The most frequent sequence types (STs) were 239, 22 and 45. The proportion of ST22 increased over the sampling period, replacing ST239 as the dominant lineage. However, ST239 remained the most prevalent among HIV-seropositive individuals who were six times more likely to be colonised with this strain than non-HIV patients (adjusted OR (aOR) 6.44, 95% confidence interval (CI) 1.94–21.36). ST45 was >24 times more likely to be associated with perianal colonisation than in the nares, axillae and groin sites (aOR 24.20, 95% CI 1.45–403.26). This study underlines the clonal replacement of MRSA in Singapore as previously reported but revealed, in addition, key strain differences between HIV-infected and non-infected individuals hospitalised in the same environment. This research received no specific grant from any funding agency, commercial or not-for-profit sectors. 2021-07-14T07:13:24Z 2021-07-14T07:13:24Z 2018 Journal Article Htun, H. L., Kyaw, W. M., de Sessions, P. F., Low, L., Hibberd, M. L., Chow, A. & Leo, Y. S. (2018). Methicillin-resistant Staphylococcus aureus colonisation : epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore. Epidemiology and Infection, 146(14), 1785-1792. https://dx.doi.org/10.1017/S0950268818001966 0950-2688 https://hdl.handle.net/10356/151668 10.1017/S0950268818001966 30019657 2-s2.0-85063870046 14 146 1785 1792 en Epidemiology and Infection © 2018 Cambridge University Press. All rights reserved. |
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Science::Medicine Epidemiology Hospital Microbiology Htun, Htet Lin Kyaw, Win Mar de Sessions, Paola Flórez Low, Louie Hibberd, Martin Lloyd Chow, Angela Leo, Yee Sin Methicillin-resistant Staphylococcus aureus colonisation : epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore |
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Current knowledge of methicillin-resistant Staphylococcus aureus (MRSA) colonisation in relation to epidemiological characteristics is incomplete. We conducted a cross-sectional study at an acute-care tertiary infectious diseases hospital of MRSA isolates identified through routine surveillance from January 2009 to December 2011. We randomly selected 205 MRSA isolates (119 inpatients) from 798 isolates (427 inpatients) for molecular profiling using multilocus sequence typing. Multilevel multinomial logistic regression was used to estimate odds ratio (OR) assessing the predilection of MRSA strains for anatomic sites, and associations of strains with human immunodeficiency virus (HIV) infection. The most frequent sequence types (STs) were 239, 22 and 45. The proportion of ST22 increased over the sampling period, replacing ST239 as the dominant lineage. However, ST239 remained the most prevalent among HIV-seropositive individuals who were six times more likely to be colonised with this strain than non-HIV patients (adjusted OR (aOR) 6.44, 95% confidence interval (CI) 1.94–21.36). ST45 was >24 times more likely to be associated with perianal colonisation than in the nares, axillae and groin sites (aOR 24.20, 95% CI 1.45–403.26). This study underlines the clonal replacement of MRSA in Singapore as previously reported but revealed, in addition, key strain differences between HIV-infected and non-infected individuals hospitalised in the same environment. |
author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Htun, Htet Lin Kyaw, Win Mar de Sessions, Paola Flórez Low, Louie Hibberd, Martin Lloyd Chow, Angela Leo, Yee Sin |
format |
Article |
author |
Htun, Htet Lin Kyaw, Win Mar de Sessions, Paola Flórez Low, Louie Hibberd, Martin Lloyd Chow, Angela Leo, Yee Sin |
author_sort |
Htun, Htet Lin |
title |
Methicillin-resistant Staphylococcus aureus colonisation : epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore |
title_short |
Methicillin-resistant Staphylococcus aureus colonisation : epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore |
title_full |
Methicillin-resistant Staphylococcus aureus colonisation : epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore |
title_fullStr |
Methicillin-resistant Staphylococcus aureus colonisation : epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore |
title_full_unstemmed |
Methicillin-resistant Staphylococcus aureus colonisation : epidemiological and molecular characteristics in an acute-care tertiary hospital in Singapore |
title_sort |
methicillin-resistant staphylococcus aureus colonisation : epidemiological and molecular characteristics in an acute-care tertiary hospital in singapore |
publishDate |
2021 |
url |
https://hdl.handle.net/10356/151668 |
_version_ |
1707050428901883904 |