Covalent cysteine targeting of Bruton’s tyrosine kinase (BTK) family by withaferin-A reduces survival of glucocorticoid-resistant multiple myeloma MM1 cells

• Main Authors: Logie, Emilie, Chirumamilla, Chandra S., Perez-Novo, Claudina, Shaw, Priyanka, Declerck, Ken, Palagani, Ajay, Rangarajan, Savithri, Cuypers, Bart, De Neuter, Nicolas, Fazil, Mobashar Hussain Urf Turabe, Verma, Navin Kumar, Bogaerts, Annemie, Laukens, Kris, Offner, Fritz, Van Vlierberghe, Pieter, Van Ostade, Xaveer, Berghe, Wim Vanden
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Withaferin A; Bruton’s Tyrosine Kinase
• Online Access: https://hdl.handle.net/10356/151836
• Institution: Nanyang Technological University

Multiple myeloma (MM) is a hematological malignancy characterized by plasma cells’ uncontrolled growth. The major barrier in treating MM is the occurrence of primary and acquired therapy resistance to anticancer drugs. Often, this therapy resistance is associated with constitutive hyperactivation of...