PPARs and tumor microenvironment : the emerging roles of the metabolic master regulators in tumor stromal–epithelial crosstalk and carcinogenesis

• Main Authors: Cheng, Hong Sheng, Yip, Yun Sheng, Lim, Eldeen Kai Yi, Wahli, Walter, Tan, Nguan Soon
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Peroxisome Proliferation-activated Receptor; Metabolic Reprogramming
• Online Access: https://hdl.handle.net/10356/151838
• Institution: Nanyang Technological University

Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for more than three decades. Consisting of three isotypes, PPARα, γ, and β/δ, these nuclear receptors are regarded as the master metabolic regulators which govern many aspects of the body energy homeostasis and cell fa...