Telomere biology disorders

• Main Authors: Kam, Michelle L. W., Nguyen, Trang T. T., Ngeow, Joanne Yuen Yie
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Anaemia; Disease Genetics
• Online Access: https://hdl.handle.net/10356/151945
• Institution: Nanyang Technological University

Telomere biology disorders (TBD) are a heterogeneous group of diseases arising from germline mutations affecting genes involved in telomere maintenance. Telomeres are DNA-protein structures at chromosome ends that maintain chromosome stability; their length affects cell replicative potential and sen...