Choriocapillaris microvasculature dysfunction in systemic hypertension

• Main Authors: Chua, Jacqueline, Le, Thu-Thao, Tan, Bingyao, Ke, Mengyuan, Li, Chi, Wong, Damon Wing Kee, Tan, Anna C. S., Lamoureux, Ecosse, Wong, Tien Yin, Chin, Calvin Woon Loong, Schmetterer, Leopold
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Biomarkers; Cardiovascular Diseases
• Online Access: https://hdl.handle.net/10356/151979
• Institution: Nanyang Technological University

We examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients and determined possible correlations with BP and renal parameters. BP levels, serum creatinine and urine microalbumin/creatinine ratio (MCR) specimens were collected. The estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. The main outcome was choriocapillaris flow deficits (CFD) metrics (density, size and numbers). The CFD occupied a larger area and were fewer in number in the hypertensive patients with poor BP control (407 ± 10 µm²; 3260 ± 61) compared to the hypertensives with good BP control (369 ± 5 µm²; 3551 ± 41) and healthy controls (365 ± 11 µm²; 3581 ± 84). Higher systolic BP (β = 9.90, 95% CI, 2.86–16.93), lower eGFR (β = − 0.85; 95% CI, − 1.58 to − 0.13) and higher urine MCR (β = 1.53, 95% CI, 0.32–2.78) were associated with larger areas of CFD. Similar significant associations with systolic BP, eGFR and urine MCR were found with number of CFD. These findings highlight the potential role of choriocapillaris imaging using SS-OCTA as an indicator of systemic microvascular abnormalities secondary to hypertensive disease.