Mitochondrial regulation of microglial immunometabolism in Alzheimer’s disease

• Main Authors: Fairley, Lauren H., Wong, Jia Hui, Barron, Anna M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Beta Amyloid; Neurodegeneration
• Online Access: https://hdl.handle.net/10356/152058
• Institution: Nanyang Technological University

Alzheimer’s disease (AD) is an age-associated terminal neurodegenerative disease with no effective treatments. Dysfunction of innate immunity is implicated in the pathogenesis of AD, with genetic studies supporting a causative role in the disease. Microglia, the effector cells of innate immunity in...