Poor birth outcomes in malaria in pregnancy : recent insights into mechanisms and prevention approaches
Pregnant women in malaria-endemic regions are susceptible to malaria in pregnancy, which has adverse consequences on birth outcomes, including having small for gestational age and preterm babies. These babies are likely to have low birthweights, which predisposes to infant mortality and lifelong mor...
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sg-ntu-dr.10356-1520602023-03-05T16:44:16Z Poor birth outcomes in malaria in pregnancy : recent insights into mechanisms and prevention approaches Chua, Caroline L. L. Hasang, Wina Rogerson, Stephen J. Teo, Andrew Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Low Birthweight Preterm Birth Pregnant women in malaria-endemic regions are susceptible to malaria in pregnancy, which has adverse consequences on birth outcomes, including having small for gestational age and preterm babies. These babies are likely to have low birthweights, which predisposes to infant mortality and lifelong morbidities. During malaria in pregnancy, Plasmodium falciparum-infected erythrocytes express a unique variant surface antigen, VAR2CSA, that mediates sequestration in the placenta. This process may initiate a range of host responses that contribute to placental inflammation and dysregulated placental development, which affects placental vasculogenesis, angiogenesis and nutrient transport. Collectively, these result in the impairment of placental functions, affecting fetal development. In this review, we provide an overview of malaria in pregnancy and the different pathological pathways leading to malaria in pregnancy-associated low birthweight. We also discuss current prevention and management strategies for malaria in pregnancy, and some potential therapeutic interventions that may improve birth outcomes. Lastly, we outline some priorities for future research that could bring us one step closer to reducing this health burden. Nanyang Technological University Published version CC received support from Ministry of Education (MOE) Fundamental Research Grant Scheme of Malaysia: ID FRGS/1/2015/SKK08/Taylor/03/2. SR and WH were supported by grants from the National Health and Medical Research Council of Australia (GNT1143946; GNT1092789). AT was supported by Nanyang Technological University Research Scholarship Block Fellowship of Singapore and Nanyang Technological University Singapore Start-up grant. 2021-11-18T06:51:59Z 2021-11-18T06:51:59Z 2021 Journal Article Chua, C. L. L., Hasang, W., Rogerson, S. J. & Teo, A. (2021). Poor birth outcomes in malaria in pregnancy : recent insights into mechanisms and prevention approaches. Frontiers in Immunology, 12, 621382-. https://dx.doi.org/10.3389/fimmu.2021.621382 1664-3224 https://hdl.handle.net/10356/152060 10.3389/fimmu.2021.621382 33790894 2-s2.0-85103314192 12 621382 en Frontiers in Immunology © 2021 Chua, Hasang, Rogerson and Teo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
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Science::Medicine Low Birthweight Preterm Birth Chua, Caroline L. L. Hasang, Wina Rogerson, Stephen J. Teo, Andrew Poor birth outcomes in malaria in pregnancy : recent insights into mechanisms and prevention approaches |
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Pregnant women in malaria-endemic regions are susceptible to malaria in pregnancy, which has adverse consequences on birth outcomes, including having small for gestational age and preterm babies. These babies are likely to have low birthweights, which predisposes to infant mortality and lifelong morbidities. During malaria in pregnancy, Plasmodium falciparum-infected erythrocytes express a unique variant surface antigen, VAR2CSA, that mediates sequestration in the placenta. This process may initiate a range of host responses that contribute to placental inflammation and dysregulated placental development, which affects placental vasculogenesis, angiogenesis and nutrient transport. Collectively, these result in the impairment of placental functions, affecting fetal development. In this review, we provide an overview of malaria in pregnancy and the different pathological pathways leading to malaria in pregnancy-associated low birthweight. We also discuss current prevention and management strategies for malaria in pregnancy, and some potential therapeutic interventions that may improve birth outcomes. Lastly, we outline some priorities for future research that could bring us one step closer to reducing this health burden. |
author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
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Lee Kong Chian School of Medicine (LKCMedicine) Chua, Caroline L. L. Hasang, Wina Rogerson, Stephen J. Teo, Andrew |
format |
Article |
author |
Chua, Caroline L. L. Hasang, Wina Rogerson, Stephen J. Teo, Andrew |
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Chua, Caroline L. L. |
title |
Poor birth outcomes in malaria in pregnancy : recent insights into mechanisms and prevention approaches |
title_short |
Poor birth outcomes in malaria in pregnancy : recent insights into mechanisms and prevention approaches |
title_full |
Poor birth outcomes in malaria in pregnancy : recent insights into mechanisms and prevention approaches |
title_fullStr |
Poor birth outcomes in malaria in pregnancy : recent insights into mechanisms and prevention approaches |
title_full_unstemmed |
Poor birth outcomes in malaria in pregnancy : recent insights into mechanisms and prevention approaches |
title_sort |
poor birth outcomes in malaria in pregnancy : recent insights into mechanisms and prevention approaches |
publishDate |
2021 |
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https://hdl.handle.net/10356/152060 |
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1759854007137861632 |