A potential quorum-sensing inhibitor for bronchiectasis therapy: quercetin–chitosan nanoparticle complex exhibiting superior inhibition of biofilm formation and swimming motility of Pseudomonas aeruginosa to the native quercetin

• Main Authors: Tran, The-Thien, Hadinoto, Kunn
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Bioengineering; Quercetin Nanoparticles; Drug-Polyelectrolyte Complexation
• Online Access: https://hdl.handle.net/10356/152069
• Institution: Nanyang Technological University

Quercetin (QUE)—a plant-derived flavonoid, is recently established as an effective quorum sensing (QS) inhibiting agent in Pseudomonas aeruginosa—the main bacterial pathogen in bronchiectasis lungs. Successful clinical application of QUE, however, is hindered by its low solubility in physiological f...