Tertiary base triple formation in the SRV-1 frameshifting pseudoknot stabilizes secondary structure components

• Main Authors: Yang, Lixia, Toh, Desiree-Faye Kaixin, Krishna, Manchugondanahalli Shivakumar, Zhong, Zhensheng, Liu, Yiyao, Wang, Shaomeng, Gong, Yubin, Chen, Gang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Melting; Genetics
• Online Access: https://hdl.handle.net/10356/152156
• Institution: Nanyang Technological University

Minor-groove base triples formed between stem 1 and loop 2 of the simian retrovirus type 1 (SRV-1) mRNA frameshifting pseudoknot are essential in stimulating -1 ribosomal frameshifting. How tertiary base triple formation affects the local stabilities of secondary structures (stem 1 and stem 2) and t...