Brain-derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer's disease

• Main Authors: Gallart-Palau, Xavier, Serra, Aida, Hase, Yoshiki, Tan, Chee Fan, Chen, Christopher P., Kalaria, Raj N., Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Bilateral Common Carotid Stenosis; Cerebral Hypoperfusion
• Online Access: https://hdl.handle.net/10356/152220
• Institution: Nanyang Technological University

Vascular factors that reduce blood flow to the brain are involved in apparition and progression of dementia. We hypothesized that cerebral hypoperfusion (CH) might alter the molecular compositions of brain intercellular communication mechanisms while affecting the neurovascular unit in preclinical a...