Improving the reproducibility of size distribution of protein crystals produced in continuous slug flow crystallizer operated at short residence time

• Main Authors: Pu, Siyu, Hadinoto, Kunn
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Chemical technology; Protein Crystallization; Continuous Crystallization
• Online Access: https://hdl.handle.net/10356/152265
• Institution: Nanyang Technological University

Continuous crystallization of proteins at short residence time and high supersaturation level is attractive in terms of the space-time yield and production efficiency. Nevertheless, it is rarely pursued due to its less-than-desirable crystal size distribution (CSD) characterized by the abundance of...