Bacterial cellulose adhesive composites for oral cavity applications

Bacterial cellulose adhesive composites for oral cavity applications

Topical approaches to oral diseases require frequent dosing due to limited wound retention times. A mucoadhesive drug delivery platform is proposed for oral wound sites with soft tissue adhesion capability of up to 7 days. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives are...

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Bibliographic Details
Main Authors: Singh, Juhi, Tan, Nigel Chew Shun, Mahadevaswamy, Usha Rani, Chanchareonsook, Nattharee, Steele, Terry W. J., Lim, Sierin
Other Authors: Interdisciplinary Graduate School (IGS)
Format: Article
Language:English
Published: 2021
Subjects:
Engineering::Chemical engineering
Bacterial Cellulose
Mucoadhesives
Bioadhesives
Photocuring
Oral Patch
Online Access:https://hdl.handle.net/10356/152714
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Institution: Nanyang Technological University
Language: English
Description
Summary:Topical approaches to oral diseases require frequent dosing due to limited wound retention times. A mucoadhesive drug delivery platform is proposed for oral wound sites with soft tissue adhesion capability of up to 7 days. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives are combined to yield flexible film platform for interfacing soft tissues in dynamic, wet environments. Structure-activity relationships evaluate UV dose and hydration state with respect to adhesive strength on soft tissue mimics. The bioadhesive composite has an adhesion strength ranging from 7-17 kPa and duration exceeding 48 hours in wet conditions under sustained shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit adhesion strength of 0.5-5 kPa and last only a few hours. The work highlights the first evaluation of BC composites for mucoadhesive treatments in the buccal cavity.

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