Bioinspired hierarchical composites

Tendons play an important role in the human body. While injuries to these soft tissues are highly common, recovery is often slow due to the poor healing ability of the tissues. To effectively create a material which can replace tendons, it should also mimic the self-healing properties and hierarchic...

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Main Author: Kathirvel Periasamy
Other Authors: Hortense Le Ferrand
Format: Final Year Project
Language:English
Published: Nanyang Technological University 2021
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Online Access:https://hdl.handle.net/10356/153038
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1530382023-03-04T15:46:13Z Bioinspired hierarchical composites Kathirvel Periasamy Hortense Le Ferrand School of Materials Science and Engineering Hortense@ntu.edu.sg Engineering::Materials::Material testing and characterization Engineering::Materials::Composite materials Tendons play an important role in the human body. While injuries to these soft tissues are highly common, recovery is often slow due to the poor healing ability of the tissues. To effectively create a material which can replace tendons, it should also mimic the self-healing properties and hierarchical structure of tendons. In this project, we have fabricated a gelatin based hydrogel which demonstrated self-healing properties without external stimuli. Tannic acid, a polyphenol sourced from plants, was chosen as the crosslinker due to its hydrophobic interactions and hydrogen bonding with gelatin. We crosslinked gelatin with tannic acid to achieve the self-healing property and added calcium phosphate (CaP) microplatelets to the polymer matrix. Alignment of the CaP platelets in the gel matrix is needed for anisotropic mechanical properties in the composite. This would allow us to create hierarchical structures. We tested the rheological properties of the gel to determine if it would be possible to control platelet alignment using magnetic fields. We found that the mechanical properties of the hydrogel could be tuned by tannic acid content. The results also revealed the thermosetting properties of the hydrogel. Bachelor of Engineering (Materials Engineering) 2021-11-01T04:03:55Z 2021-11-01T04:03:55Z 2021 Final Year Project (FYP) Kathirvel Periasamy (2021). Bioinspired hierarchical composites. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/153038 https://hdl.handle.net/10356/153038 en application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Materials::Material testing and characterization
Engineering::Materials::Composite materials
spellingShingle Engineering::Materials::Material testing and characterization
Engineering::Materials::Composite materials
Kathirvel Periasamy
Bioinspired hierarchical composites
description Tendons play an important role in the human body. While injuries to these soft tissues are highly common, recovery is often slow due to the poor healing ability of the tissues. To effectively create a material which can replace tendons, it should also mimic the self-healing properties and hierarchical structure of tendons. In this project, we have fabricated a gelatin based hydrogel which demonstrated self-healing properties without external stimuli. Tannic acid, a polyphenol sourced from plants, was chosen as the crosslinker due to its hydrophobic interactions and hydrogen bonding with gelatin. We crosslinked gelatin with tannic acid to achieve the self-healing property and added calcium phosphate (CaP) microplatelets to the polymer matrix. Alignment of the CaP platelets in the gel matrix is needed for anisotropic mechanical properties in the composite. This would allow us to create hierarchical structures. We tested the rheological properties of the gel to determine if it would be possible to control platelet alignment using magnetic fields. We found that the mechanical properties of the hydrogel could be tuned by tannic acid content. The results also revealed the thermosetting properties of the hydrogel.
author2 Hortense Le Ferrand
author_facet Hortense Le Ferrand
Kathirvel Periasamy
format Final Year Project
author Kathirvel Periasamy
author_sort Kathirvel Periasamy
title Bioinspired hierarchical composites
title_short Bioinspired hierarchical composites
title_full Bioinspired hierarchical composites
title_fullStr Bioinspired hierarchical composites
title_full_unstemmed Bioinspired hierarchical composites
title_sort bioinspired hierarchical composites
publisher Nanyang Technological University
publishDate 2021
url https://hdl.handle.net/10356/153038
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